Dietary Nutrients, Gut Microbiota, and Cardiac Function: From Metabolic Mechanisms to Clinical Applications
Lucia Scisciola; Manuela Giovanna Basilicata; Marta Belmonte; Ada Pesapane; Rosaria Anna Fontanella; Nunzia Balzano; A. Palazzo; Rashmi R. Joshi · 2026 · Nutrients
WASTE classifies this as Negative / Null Result Report · AI classification, approximate
The study found no significant effect — useful as a negative control or null benchmark for your own design.
Abstract
BACKGROUND: The heart depends on a continuous and flexible energy supply from fatty acids, glucose, and other substrates. Emerging evidence shows that gut microbiota-derived metabolites-such as trimethylamine-N-oxide (TMAO), short-chain fatty acids (SCFAs), secondary bile acids, indoles, phenylacetylglutamine (PAGln), and branched-chain amino acids-modulate cardiac metabolism and function. Although clinical evidence linking these metabolites to cardiovascular outcomes is expanding, most data remain associative, with limited causal or interventional proof. METHODS: A comprehensive narrative rev
Abstract by Lucia Scisciola; Manuela Giovanna Basilicata; Marta Belmonte; Ada Pesapane; Rosaria Anna Fontanella; Nunzia Balzano; A. Palazzo; Rashmi R. Joshi, Nutrients (2026) — licensed CC BY 4.0.
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Metadata source: OpenAlex · DOI 10.3390/nu18030467