Wildtype epidermal growth factor receptor ( Egfr ) is not required for daily locomotor or masking behavior in mice
Sancar Aziz; Mankinen Richard W; Lee Daekee; Thompson Carol L; Roberts Reade B; Threadgill David W · 2006 · Journal of Circadian Rhythms
WASTE classifies this as Negative / Null Result Report · AI classification, approximate
The study found no significant effect — useful as a negative control or null benchmark for your own design.
The finding, in one line
“Subsequenlty, a larger study using the same genetically mixed background failed to replicate the original findings.”
Abstract
Abstract Background Recent studies have implicated the epidermal growth factor receptor (EGFR) within the subparaventricular zone as being a major mediator of locomotor and masking behaviors in mice. The results were based on small cohorts of mice homozygous for the hypomorphic Egfr wa 2 allele on a mixed, genetically uncontrolled background, and on intraventricular infusion of exogenous EGFR ligands. Subsequenlty, a larger study using the same genetically mixed background failed to replicate the original findings. Since both previous approaches were susceptible to experimental artifacts relat
Abstract by Sancar Aziz; Mankinen Richard W; Lee Daekee; Thompson Carol L; Roberts Reade B; Threadgill David W, Journal of Circadian Rhythms (2006) — licensed CC BY 4.0.
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Metadata source: DOAJ · DOI 10.1186/1740-3391-4-15