Ex vivo infection model for Francisella using human lung tissue
Kristin Köppen; Diana Fatykhova; Gudrun Holland; Jessica Rauch; Dennis Tappe; Mareike Graff; Kerstin Rydzewski; Andreas C. Hocke · 2023 · Frontiers in Cellular and Infection Microbiology
WASTE classifies this as Negative / Null Result Report · AI classification, approximate
The study found no significant effect — useful as a negative control or null benchmark for your own design.
Abstract
Introduction Tularemia is mainly caused by Francisella tularensis ( Ft ) subsp. tularensis ( Ftt ) and Ft subsp. holarctica ( Ftt ) in humans and in more than 200 animal species including rabbits and hares. Human clinical manifestations depend on the route of infection and range from flu-like symptoms to severe pneumonia with a mortality rate up to 60% without treatment. So far, only 2D cell culture and animal models are used to study Francisella virulence , but the gained results are transferable to human infections only to a certain extent. Method In this study, we firstly established an ex
Abstract by Kristin Köppen; Diana Fatykhova; Gudrun Holland; Jessica Rauch; Dennis Tappe; Mareike Graff; Kerstin Rydzewski; Andreas C. Hocke, Frontiers in Cellular and Infection Microbiology (2023) — licensed CC BY 4.0.
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Metadata source: OpenAlex · DOI 10.3389/fcimb.2023.1224356