Lipid nanoparticle screening in nonhuman primates with minimal loss of life
Ryan Zenhausern; Bora Jang; Elisa Schrader Echeverri; Kara Gentry; Randi Calkins; Elizabeth Curran; Jennifer Wood; Rachelle L. Stammen · 2025 · Nature Biotechnology
WASTE classifies this as Negative / Null Result Report · AI classification, approximate
The study found no significant effect — useful as a negative control or null benchmark for your own design.
Abstract (excerpt)
Understanding how well delivery in mice predicts delivery in nonhuman primates (NHPs) could make lipid nanoparticle (LNP) discovery more efficient. Yet, few LNP-mRNA drug candidates are tested in NHPs, in part because the experiments…
Excerpt shown for reference under fair use — read the full paper at the publisher.
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Metadata source: OpenAlex · DOI 10.1038/s41587-025-02711-y