Human brain changes after first psilocybin use
Terence J. Lyons; Merle Spriggs; Leevi Kerkelä; FE Rosas; Leor Roseman; P. Mediano; Carsten Timmermann; Lena Oestreich · 2026 · Nature Communications
WASTE classifies this as Negative / Null Result Report · AI classification, approximate
The study found no significant effect — useful as a negative control or null benchmark for your own design.
Abstract
Psychedelics have robust effects on acute brain function and long-term behavior but whether they also cause enduring functional and anatomical brain changes is largely unknown. In an exploratory, placebo-controlled, within-subjects, electroencephalography (EEG), and magnetic resonance imaging (MRI) study in 28 healthy, entirely psychedelic-naive participants, anatomical and functional brain changes are detected from one-hour to one-month after a single high-dose (25 mg) of psilocybin. Increases in cognitive flexibility, psychological insight, and well-being are seen at one-month. Diffusion ten
Abstract by Terence J. Lyons; Merle Spriggs; Leevi Kerkelä; FE Rosas; Leor Roseman; P. Mediano; Carsten Timmermann; Lena Oestreich, Nature Communications (2026) — licensed CC BY 4.0.
About to run something similar?
Run an AI Precheck on your own design to catch failure modes like this one before you spend the time. Your first desk check is free.
Related failures
Our Princess Is in Another Castle
Negative / Null Result ReportUsing Psychological Artificial Intelligence (Tess) to Relieve Symptoms of Depression and Anxiety: Randomized Controlled Trial
Negative / Null Result ReportHow Replicable Are Links Between Personality Traits and Consequential Life Outcomes? The Life Outcomes of Personality Replication Project
Negative / Null Result ReportThe cross-cultural validity of posttraumatic stress disorder: implications for DSM-5
Negative / Null Result ReportPsychiatric and medical correlates of DSM‐5 eating disorders in a nationally representative sample of adults in the United States
Negative / Null Result ReportRomantic relationships and the physical and mental health of college students
WASTE indexes this work — it does not host or republish it. Failure-type classification is automated and approximate.
Metadata source: OpenAlex · DOI 10.1038/s41467-026-71962-3