Limits of long-term selection against Neandertal introgression
Martin Petr; Svante Pääbo; Janet Kelso; Benjamin Vernot · 2019 · Proceedings of the National Academy of Sciences
WASTE classifies this as Negative / Null Result Report · AI classification, approximate
The study found no significant effect — useful as a negative control or null benchmark for your own design.
Abstract
Several studies have suggested that introgressed Neandertal DNA was subjected to negative selection in modern humans. A striking observation in support of this is an apparent monotonic decline in Neandertal ancestry observed in modern humans in Europe over the past 45,000 years. Here, we show that this decline is an artifact likely caused by gene flow between modern human populations, which is not taken into account by statistics previously used to estimate Neandertal ancestry. When we apply a statistic that avoids assumptions about modern human demography by taking advantage of two high-cover
Abstract by Martin Petr; Svante Pääbo; Janet Kelso; Benjamin Vernot, Proceedings of the National Academy of Sciences (2019) — licensed CC BY 4.0.
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Metadata source: OpenAlex · DOI 10.1073/pnas.1814338116