Temporal evolution of breast cancer brain metastases treatments and outcomes
Michele Bottosso; Gaia Griguolo; Severine Guiu; Maria Cristina Guarascio; Caroline Bailleux; Federica Miglietta; Anna Chiara Cattelan; Christian Zurlo · 2025 · npj Breast Cancer
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Abstract
Abstract Brain metastases (BMs) are a common complication of advanced breast cancer (BC), and their management has significantly evolved. We evaluated the clinical impact of these changes dividing patients diagnosed with BCBMs at three Institutions according to year of BMs diagnosis: 2000-2007 (group A), 2008-2014 (group B) and 2015-2022 (group C). Stereotactic radiotherapy increased (p < 0.001), and WBRT decreased (p = 0.010) over time. Among HER2+ BC patients, more received anti-HER2 therapy after BM diagnosis in recent years (p < 0.011). Overall survival (OS) did not improve in the entire c
Abstract by Michele Bottosso; Gaia Griguolo; Severine Guiu; Maria Cristina Guarascio; Caroline Bailleux; Federica Miglietta; Anna Chiara Cattelan; Christian Zurlo, npj Breast Cancer (2025) — licensed CC BY 4.0.
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Metadata source: DOAJ · DOI 10.1038/s41523-025-00735-w