The HDAC inhibitor romidepsin renders liver cancer vulnerable to RTK targeting and immunologically active
Celia Sequera; Margherita Grattarola; Floriane Cannet; Aurélie Dobric; Paula Michea Veloso; Melissa Methia; Sylvie Richelme; Abdessamad El Kaoutari · 2025 · Nature Communications
WASTE classifies this as Negative / Null Result Report · AI classification, approximate
The study found no significant effect — useful as a negative control or null benchmark for your own design.
Abstract (excerpt)
Histone deacetylases (HDACs) are epigenetic regulators frequently altered in cancer. Here we report that overexpression of HDAC1/2 occurs in Hepatocellular Carcinoma (HCC) patients, correlating with poor prognosis. We show that romidepsin,…
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Metadata source: OpenAlex · DOI 10.1038/s41467-025-62934-0