Association of lysophosphatidic acids with cerebrospinal fluid biomarkers and progression to Alzheimer’s disease
Shahzad Ahmad; Adelina Orellana; Isabelle Köhler; Lutz Frölich; Itziar de Rojas; Silvia Gil; Merçé Boada; Isabel Hernández · 2020 · Alzheimer s Research & Therapy
WASTE classifies this as Negative / Null Result Report · AI classification, approximate
The study found no significant effect — useful as a negative control or null benchmark for your own design.
Abstract
BACKGROUND: Lysophosphatidic acids (LPAs) are bioactive signaling phospholipids that have been implicated in Alzheimer's disease (AD). It is largely unknown whether LPAs are associated with AD pathology and progression from mild cognitive impairment (MCI) to AD. METHODS: The current study was performed on cerebrospinal fluid (CSF) and plasma samples of 182 MCI patients from two independent cohorts. We profiled LPA-derived metabolites using liquid chromatography-mass spectrometry. We evaluated the association of LPAs with CSF biomarkers of AD, Aβ-42, p-tau, and total tau levels overall and stra
Abstract by Shahzad Ahmad; Adelina Orellana; Isabelle Köhler; Lutz Frölich; Itziar de Rojas; Silvia Gil; Merçé Boada; Isabel Hernández, Alzheimer s Research & Therapy (2020) — licensed CC BY 4.0.
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Metadata source: OpenAlex · DOI 10.1186/s13195-020-00680-9