Hypoxic microenvironment in cancer: role in metabolic reprogramming
Niti Sureka; Rashi Maheshwari; Amit H Agravat; Shweta Singhal; Shamsuz Zaman; Bhavika Rishi; Fouzia Siraj; Sufian Zaheer · 2026 · Frontiers in Oncology
WASTE classifies this as Negative / Null Result Report · AI classification, approximate
The study found no significant effect — useful as a negative control or null benchmark for your own design.
Abstract
Hypoxia, a defining hallmark of solid tumors, arises from structurally and functionally abnormal vasculature, rapid cellular proliferation, and impaired perfusion, resulting in chronic and cycling oxygen deprivation within the tumor massThe hypoxic tumor microenvironment orchestrates extensive molecular reprogramming primarily through stabilization and activation of hypoxia-inducible factors (HIF-1α and HIF-2α), which regulate broad transcriptional networks governing metabolism, angiogenesis, stemness, invasion, and immune modulation. Under low oxygen tension, tumor cells shift toward aerobic
Abstract by Niti Sureka; Rashi Maheshwari; Amit H Agravat; Shweta Singhal; Shamsuz Zaman; Bhavika Rishi; Fouzia Siraj; Sufian Zaheer, Frontiers in Oncology (2026) — licensed CC BY 4.0.
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Metadata source: OpenAlex · DOI 10.3389/fonc.2026.1771365