Limited overlap between genetic effects on disease susceptibility and disease survival
Zhiyu Yang; Fanny‐Dhelia Pajuste; Kristina Zguro; Yipeng Cheng; Danielle E. Kurant; Andrea Eoli; Julian Wanner; Bradley Jermy · 2025 · Nature Genetics
WASTE classifies this as Negative / Null Result Report · AI classification, approximate
The study found no significant effect — useful as a negative control or null benchmark for your own design.
Abstract
Abstract Understanding disease progression is of high biological and clinical interest. Unlike disease susceptibility, whose genetic basis has been abundantly studied, less is known about the genetics of disease progression and its overlap with disease susceptibility. Considering nine common diseases ( n cases ranging from 11,980 to 124,682) across seven biobanks, we systematically compared genetic architectures of susceptibility and progression, defined as disease-specific mortality. We identified only one locus substantially associated with disease-specific mortality and showed that, at a si
Abstract by Zhiyu Yang; Fanny‐Dhelia Pajuste; Kristina Zguro; Yipeng Cheng; Danielle E. Kurant; Andrea Eoli; Julian Wanner; Bradley Jermy, Nature Genetics (2025) — licensed CC BY 4.0.
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Metadata source: OpenAlex · DOI 10.1038/s41588-025-02342-8