Case Report: Persistent Hypogammaglobulinemia More Than 10 Years After Rituximab Given Post-HSCT
Fanny Luterbacher; Fanette Bernard; Frédéric Baleydier; Emmanuelle Ranza; Emmanuelle Ranza; Peter Jandus; Geraldine Blanchard-Rohner · 2021 · Frontiers in Immunology
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Abstract
Rituximab (RTX) is an anti-CD20 monoclonal antibody that targets B cells—from the immature pre-B-cell stage in the bone marrow to mature circulating B cells—while preserving stem cells and plasma cells. It is used to treat autoimmune diseases, hematological malignancies, or complications after hematopoietic stem cell transplantation (HSCT). Its safety profile is acceptable; however, a subset of patients can develop persistent hypogammaglobulinemia and associated severe complications, especially in pediatric populations. We report the unrelated cases of two young men aged 17 and 22, presenting
Abstract by Fanny Luterbacher; Fanette Bernard; Frédéric Baleydier; Emmanuelle Ranza; Emmanuelle Ranza; Peter Jandus; Geraldine Blanchard-Rohner, Frontiers in Immunology (2021) — licensed CC BY 4.0.
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Metadata source: DOAJ · DOI 10.3389/fimmu.2021.773853