Mitochondrial Dysfunction in Cardiomyopathy and Heart Failure: From Energetic Collapse to Therapeutic Opportunity
Nikola Pavlović; Petar Todorović; Mirko Maglica; Marko Kumrić; Katarina Vukojević; Zenon Pogorelić; Joško Božić · 2025 · Biomolecules
WASTE classifies this as Negative / Null Result Report · AI classification, approximate
The study found no significant effect — useful as a negative control or null benchmark for your own design.
Abstract
The heart’s relentless contractile activity depends critically on mitochondrial function to meet its extraordinary bioenergetic demands. Mitochondria, through oxidative phosphorylation, not only supply ATP but also regulate metabolism, calcium homeostasis, and apoptotic signaling, ensuring cardiomyocyte viability and cardiac function. Mitochondrial dysfunction is a hallmark of cardiomyopathies and heart failure, characterized by impaired oxidative phosphorylation, excessive production of reactive oxygen species (ROS), dysregulated calcium handling, and disturbances in mitochondrial dynamics an
Abstract by Nikola Pavlović; Petar Todorović; Mirko Maglica; Marko Kumrić; Katarina Vukojević; Zenon Pogorelić; Joško Božić, Biomolecules (2025) — licensed CC BY 4.0.
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Metadata source: OpenAlex · DOI 10.3390/biom15111572