Validation of the 2017 revision of the WHO chronic myelomonocytic leukemia categories
Sanam Loghavi; Dawen Sui; Peng Wei; Guillermo Garcia-Manero; Sherry Pierce; Mark J. Routbort; Elias J. Jabbour; Naveen Pemmaraju · 2018 · Blood Advances
WASTE classifies this as Negative / Null Result Report · AI classification, approximate
The study found no significant effect — useful as a negative control or null benchmark for your own design.
Abstract
Abstract: The 2017 revision of the World Health Organization (WHO) classification includes substantial changes to the subclassification of chronic myelomonocytic leukemia (CMML): (1) a 3-tiered blast-based scheme including a novel “CMML-0” category replacing a 2-tiered system in place since 2001 and (2) 2 CMML subtypes, myelodysplastic (MDS-CMML) and myeloproliferative (MP-CMML), based on a white blood cell count cutoff of 13 × 109/L. The clinical utility of this subclassification scheme, particularly the expansion of blast-based subgroups, has not been validated. In this study, a large single
Abstract by Sanam Loghavi; Dawen Sui; Peng Wei; Guillermo Garcia-Manero; Sherry Pierce; Mark J. Routbort; Elias J. Jabbour; Naveen Pemmaraju, Blood Advances (2018) — licensed CC BY 4.0.
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Metadata source: DOAJ · DOI 10.1182/bloodadvances.2018019224