Ten-year update of HOBOE phase III trial comparing triptorelin plus either tamoxifen or letrozole or zoledronic acid + letrozole in premenopausal hormone receptor-positive early breast cancer patients
Adriano Gravina; P. Gargiulo; Michelino De Laurentiis; Laura Arenare; Sabino De Placido; M. Orditura; Saverio Cinieri; F Riccardi · 2025 · ESMO Open
WASTE classifies this as Negative / Null Result Report · AI classification, approximate
The study found no significant effect — useful as a negative control or null benchmark for your own design.
Abstract (excerpt)
BACKGROUND: The Hormonal Bone Effects (HOBOE) study tested whether adjuvant triptorelin plus either letrozole (L) or zoledronic acid (Z) plus L (ZL) was more effective than tamoxifen (T) in premenopausal patients with hormone…
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Metadata source: OpenAlex · DOI 10.1016/j.esmoop.2024.104085