Umbrella and basket trials in oncology: ethical challenges
Karolina Strzebońska; Marcin Waligóra · 2019 · BMC Medical Ethics
WASTE classifies this as Negative / Null Result Report · AI classification, approximate
The study found no significant effect — useful as a negative control or null benchmark for your own design.
Abstract
BACKGROUND: Novel precision oncology trial designs, such as basket and umbrella trials, are designed to test new anticancer agents in more effective and affordable ways. However, they present some ethical concerns referred to scientific validity, risk-benefit balance and informed consent. Our aim is to discuss these issues in basket and umbrella trials, giving examples of two ongoing cancer trials: NCI-MATCH (National Cancer Institute - Molecular Analysis for Therapy Choice) and Lung-MAP (Lung Cancer Master Protocol) study. MAIN BODY: We discuss three ethical requirements for clinical trials w
Abstract by Karolina Strzebońska; Marcin Waligóra, BMC Medical Ethics (2019) — licensed CC BY 4.0.
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Metadata source: OpenAlex · DOI 10.1186/s12910-019-0395-5