Effects of short‐term tofogliflozin treatment on the insulin secretory capacity of people with type 2 diabetes: A randomized controlled trial, the TOP‐ELM study
Maiko Miyamoto; Aika Miya; Akinobu Nakamura; Yuka Takahashi; Yuki Yamauchi; Shingo Yanagiya; Takahiro Takase; Mayuko Ono · 2026 · Journal of Diabetes Investigation
WASTE classifies this as Negative / Null Result Report · AI classification, approximate
The study found no significant effect — useful as a negative control or null benchmark for your own design.
Abstract
ABSTRACT Aims/Introduction We aimed to explore the short‐term effects of tofogliflozin on the insulin secretory capacity of people with type 2 diabetes. Materials and Methods We performed a multicenter, prospective, randomized, active‐controlled, open‐label, parallel‐group comparison study of people with type 2 diabetes aged 20–89 years, with hemoglobin A1c (HbA1c) 6.5%–9.0%, not previously treated with antihyperglycemic agents. The participants were randomly assigned to a group that received 20 mg tofogliflozin per day or a group that received 500 mg metformin per day for 4 weeks. Fasting blo
Abstract by Maiko Miyamoto; Aika Miya; Akinobu Nakamura; Yuka Takahashi; Yuki Yamauchi; Shingo Yanagiya; Takahiro Takase; Mayuko Ono, Journal of Diabetes Investigation (2026) — licensed CC BY 4.0.
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Metadata source: DOAJ · DOI 10.1111/jdi.70245