Lack of effect of Lactobacillus rhamnosus GG and Bifidobacterium lactis Bb12 on beta-cell function in children with newly diagnosed type 1 diabetes: a randomised controlled trial
Hania Szajewska; Agnieszka Szypowska; Lidia Groele; Mieczysław Szalecki; Jolanta Świderska; Marta Wysocka-Mincewicz; Agnieszka Ochocińska; Anna Stelmaszczyk-Emmel · 2021 · BMJ Open Diabetes Research & Care
WASTE classifies this as Negative / Null Result Report · AI classification, approximate
The study found no significant effect — useful as a negative control or null benchmark for your own design.
Abstract
Introduction The gut microbiota may be relevant in the development of type 1 diabetes (T1D). We examined the effects of Lactobacillus rhamnosus GG and Bifidobacterium lactis Bb12 on beta-cell function in children with newly diagnosed T1D.Research design and methods Children aged 8–17 years with newly (within 60 days) diagnosed T1D were enrolled in a double-blind, randomised controlled trial in which they received L. rhamnosus GG and B. lactis Bb12 at a dose of 109 colony-forming units or placebo, orally, once daily, for 6 months. The follow-up was for 12 months. The primary outcome measure was
Abstract by Hania Szajewska; Agnieszka Szypowska; Lidia Groele; Mieczysław Szalecki; Jolanta Świderska; Marta Wysocka-Mincewicz; Agnieszka Ochocińska; Anna Stelmaszczyk-Emmel, BMJ Open Diabetes Research & Care (2021) — licensed CC BY 4.0.
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Metadata source: DOAJ · DOI 10.1136/bmjdrc-2020-001523