Repression of tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) but not its receptors during oral cancer progression
Muller Susan; Bouquot Jerry; Lou Yahuan; Wu Jean; Baucum Darryl C; Vigneswaran Nadarajah; Zacharias Wolfgang · 2007 · BMC Cancer
WASTE classifies this as Negative / Null Result Report · AI classification, approximate
The study found no significant effect — useful as a negative control or null benchmark for your own design.
Abstract
Abstract Background TRAIL plays an important role in host immunosurveillance against tumor progression, as it induces apoptosis of tumor cells but not normal cells, and thus has great therapeutic potential for cancer treatment. TRAIL binds to two cell-death-inducing (DR4 and DR5) and two decoy (DcR1, and DcR2) receptors. Here, we compare the expression levels of TRAIL and its receptors in normal oral mucosa (NOM), oral premalignancies (OPM), and primary and metastatic oral squamous cell carcinomas (OSCC) in order to characterize the changes in their expression patterns during OSCC initiation a
Abstract by Muller Susan; Bouquot Jerry; Lou Yahuan; Wu Jean; Baucum Darryl C; Vigneswaran Nadarajah; Zacharias Wolfgang, BMC Cancer (2007) — licensed CC BY 4.0.
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Metadata source: DOAJ · DOI 10.1186/1471-2407-7-108