Single-cell sequencing data reveal widespread recurrence and loss of mutational hits in the life histories of tumors
Jack Kuipers; Katharina Jahn; Benjamin J. Raphael; Niko Beerenwinkel · 2017 · Genome Research
WASTE classifies this as Negative / Null Result Report · AI classification, approximate
The study found no significant effect — useful as a negative control or null benchmark for your own design.
Abstract (excerpt)
Intra-tumor heterogeneity poses substantial challenges for cancer treatment. A tumor's composition can be deduced by reconstructing its mutational history. Central to current approaches is the infinite sites assumption that every genomic…
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Metadata source: OpenAlex · DOI 10.1101/gr.220707.117