Comparative evaluation of Compritol® HD5 ATO with Sodium Stearyl Fumarate and PEG 6000 as amphiphilic, hydrodispersible pharmaceutical lubricants
Chhanda Kapadia; Ketkee Deshmukh · 2017 · Journal of Excipients and Food Chemicals
WASTE classifies this as Negative / Null Result Report · AI classification, approximate
The study found no significant effect — useful as a negative control or null benchmark for your own design.
Abstract
Hydrophobic lubricants are commonly used to reduce the frictional forces generated during tableting but impart a hydrophobic film on the surface of the powder or granules. This negatively affects the performance properties of the resultant tablets by slowing disintegration and dissolution, which is especially problematic in the case of orally disintegrating tablets. In the present study a comparative evaluation of the lubricant capacity of Compritol® HD5 ATO was performed with commonly used amphiphilic lubricants, sodium stearyl fumarate and PEG 6000. The effect of concentration and mixing tim
Abstract by Chhanda Kapadia; Ketkee Deshmukh, Journal of Excipients and Food Chemicals (2017) — licensed CC BY 4.0.
About to run something similar?
Run an AI Precheck on your own design to catch failure modes like this one before you spend the time. Your first desk check is free.
Related failures
Screening and enzymatic characterization study of high-yield pprotease-producing bacterial strains derived from Shiping stinky tofu
Negative / Null Result ReportOptimization of Non-dairy Dessert Formulation based on Almond Milk Containing Tragacanth Gum and Stevia Sweetener
Negative / Null Result ReportOptimize the Instantaneous High Temperature Sterilization Process of Ilex kudingcha Based on Multiple Index Analysis
Negative / Null Result ReportFreezing Characteristics and Metabolite Analysis of Edible Cassava Root
Negative / Null Result ReportEffects of pre-freezing and sucrose impregnation methods on the quality of freeze-dried apple slices
Negative / Null Result ReportEffect of Adding Kaffir Lime Leaf Powder (Citrus hystrix) and Citronella Leaf Powder (Cymbopogon nardus) in Salted Egg on pH, Antioxidant, Moisture Content, and Organoleptics
WASTE indexes this work — it does not host or republish it. Failure-type classification is automated and approximate.
Metadata source: DOAJ