Comparing qPCR and DNA methylation-based measurements of telomere length in a high-risk pediatric cohort
Waylon J. Hastings; Laura Etzel; Christine M. Heim; Jennie G. Noll; Emma J. Rose; Hannah M. C. Schreier; Chad E. Shenk; Xin Tang · 2022 · Aging
WASTE classifies this as Negative / Null Result Report · AI classification, approximate
The study found no significant effect — useful as a negative control or null benchmark for your own design.
Abstract
Various approaches exist to assess population differences in biological aging. Telomere length (TL) is one such measure, and is associated with disease, disability and early mortality. Yet, issues surrounding precision and reproducibility are a concern for TL measurement. An alternative method to estimate TL using DNA methylation (DNAmTL) was recently developed. Although DNAmTL has been characterized in adult and elderly cohorts, its utility in pediatric populations remains unknown. We examined the comparability of leukocyte TL measurements generated using qPCR (absolute TL; aTL) to those esti
Abstract by Waylon J. Hastings; Laura Etzel; Christine M. Heim; Jennie G. Noll; Emma J. Rose; Hannah M. C. Schreier; Chad E. Shenk; Xin Tang, Aging (2022) — licensed CC BY 4.0.
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Metadata source: OpenAlex · DOI 10.18632/aging.203849