A short-acting psychedelic intervention for major depressive disorder: a phase IIa randomized placebo-controlled trial
David Erritzøe; Tommaso Barba; Tiffanie Benway; Zelah Joel; Meghan Good; Marie Layzell; Michelle Baker Jones; Graham Campbell · 2026 · Nature Medicine
WASTE classifies this as Replication Failure · AI classification, approximate
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Abstract
Major depressive disorder (MDD) is a leading cause of disability worldwide, yet many patients have inadequate responses to current treatments. Dimethyltryptamine (DMT), a serotonergic psychedelic with rapid onset and short duration, shows promise as a potential antidepressant (AD), although clinical evidence in MDD remains limited. We conducted a phase IIa, double-blind, placebo-controlled, randomized clinical trial to evaluate the efficacy and safety of intravenous DMT (SPL026; DMT fumarate) in adults with moderate-to-severe MDD. Participants received a single 21.5-mg dose of DMT or placebo i
Abstract by David Erritzøe; Tommaso Barba; Tiffanie Benway; Zelah Joel; Meghan Good; Marie Layzell; Michelle Baker Jones; Graham Campbell, Nature Medicine (2026) — licensed CC BY 4.0.
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Metadata source: OpenAlex · DOI 10.1038/s41591-025-04154-z