Gut Microbiota-Derived Short-Chain Fatty Acids in Inflammatory Bowel Disease: Mechanistic Insights into Gut Inflammation, Barrier Function, and Therapeutic Potential
Roberta Ottria; Susan Mirmajidi; Pierangela Ciuffreda · 2026 · International Journal of Molecular Sciences
WASTE classifies this as Negative / Null Result Report · AI classification, approximate
The study found no significant effect — useful as a negative control or null benchmark for your own design.
Abstract
This review delves into the complex relationship between short-chain fatty acids (SCFAs) produced by the gut microbiota and inflammatory bowel disease (IBD). IBD, which includes Crohn's disease and ulcerative colitis, is a group of chronic gastrointestinal disorders with an increasing global incidence. Despite extensive research, the exact etiopathogenesis remains elusive, although a complex interplay involving genetic predisposition, environmental influences, and abnormal immune responses against commensal gut microbes is widely recognized. SCFAs, primarily acetate and butyrate, emerge as key
Abstract by Roberta Ottria; Susan Mirmajidi; Pierangela Ciuffreda, International Journal of Molecular Sciences (2026) — licensed CC BY 4.0.
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Metadata source: OpenAlex · DOI 10.3390/ijms27021095