Remodeling of central metabolism in invasive breast cancer compared to normal breast tissue – a GC-TOFMS based metabolomics study
Jan Budczies; Carsten Denkert; Berit Müller; Scarlet Brockmöller; Frederick Klauschen; Balázs Győrffy; Manfred Dietel; Christiane Richter-Ehrenstein · 2012 · BMC Genomics
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The study found no significant effect — useful as a negative control or null benchmark for your own design.
Abstract
BACKGROUND: Changes in energy metabolism of the cells are common to many kinds of tumors and are considered a hallmark of cancer. Gas chromatography followed by time-of-flight mass spectrometry (GC-TOFMS) is a well-suited technique to investigate the small molecules in the central metabolic pathways. However, the metabolic changes between invasive carcinoma and normal breast tissues were not investigated in a large cohort of breast cancer samples so far. RESULTS: A cohort of 271 breast cancer and 98 normal tissue samples was investigated using GC-TOFMS-based metabolomics. A total number of 468
Abstract by Jan Budczies; Carsten Denkert; Berit Müller; Scarlet Brockmöller; Frederick Klauschen; Balázs Győrffy; Manfred Dietel; Christiane Richter-Ehrenstein, BMC Genomics (2012) — licensed CC BY 4.0.
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Metadata source: OpenAlex · DOI 10.1186/1471-2164-13-334