Biological aging and generational shifts in early-onset cancer risk
Ruiyi Tian; Xiaoyu Zong; Duo Ren; Stefani Tica; Daniel Y. Hong; Oluseye K. Oduyale; Jason Daniel Buenrostro; Ramaswamy Govindan · 2026 · Nature Medicine
WASTE classifies this as Negative / Null Result Report · AI classification, approximate
The study found no significant effect — useful as a negative control or null benchmark for your own design.
Abstract
Abstract Incidence of early-onset cancer is rising globally in recent generations, which underscores the need to elucidate the influence of emerging generational risk factors. Systemic and organ-specific aging reflects the cumulative impact of exposures and may provide an integrative and complementary approach to understand early-onset cancer risk. Here among 154,169 young adults from the United Kingdom Biobank, systemic aging measured by PhenoAge increased across birth cohorts, with 23% s.d. increase for those born 1965–1974 versus 1950–1954, and was associated with early-onset solid cancer r
Abstract by Ruiyi Tian; Xiaoyu Zong; Duo Ren; Stefani Tica; Daniel Y. Hong; Oluseye K. Oduyale; Jason Daniel Buenrostro; Ramaswamy Govindan, Nature Medicine (2026) — licensed CC BY 4.0.
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Metadata source: OpenAlex · DOI 10.1038/s41591-026-04448-w