Age-Dependent Changes in Bone Architecture, Patterning, and Biomechanics During Skeletal Regeneration
Kevin Hoffseth; Emily Busse; Josue Jaramillo; Jennifer Simkin; Michelle Lacey; Mimi C. Sammarco · 2021 · Frontiers in Cell and Developmental Biology
WASTE classifies this as Negative / Null Result Report · AI classification, approximate
The study found no significant effect — useful as a negative control or null benchmark for your own design.
Abstract
Mouse digit amputation provides a useful model of bone growth after injury, in that the injury promotes intramembranous bone formation in an adult animal. The digit tip is composed of skin, nerves, blood vessels, bones, and tendons, all of which regenerate after digit tip amputation, making it a powerful model for multi-tissue regeneration. Bone integrity relies upon a balanced remodeling between bone resorption and formation, which, when disrupted, results in changes to bone architecture and biomechanics, particularly during aging. In this study, we used recently developed techniques to evalu
Abstract by Kevin Hoffseth; Emily Busse; Josue Jaramillo; Jennifer Simkin; Michelle Lacey; Mimi C. Sammarco, Frontiers in Cell and Developmental Biology (2021) — licensed CC BY 4.0.
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Metadata source: DOAJ · DOI 10.3389/fcell.2021.749055