Identification of human gut bacteria that produce bioactive serotonin and promote colonic innervation
Chiara H. Moretti; E. Grasset; Jiaying Zhu; Gaohua Yang; Louise E. Olofsson; Muhammad Tanweer Khan; Per‐Olof Bergh; Jee‐Hwan Oh · 2025 · Cell Reports
WASTE classifies this as Negative / Null Result Report · AI classification, approximate
The study found no significant effect — useful as a negative control or null benchmark for your own design.
Abstract
The gut microbiota regulates host intestinal serotonin synthesis, thereby promoting the development and maintenance of the enteric nervous system, which controls bowel motility. Functional bowel disorders, including irritable bowel syndrome, are associated with altered serotonin levels and gut microbiota composition. However, it is unclear if the gut microbiota can synthesize bioactive serotonin, which may affect enteric nervous system development. Here, we identify a consortium of the human gut bacteria Limosilactobacillus mucosae and Ligilactobacillus ruminis that synthesizes serotonin in vi
Abstract by Chiara H. Moretti; E. Grasset; Jiaying Zhu; Gaohua Yang; Louise E. Olofsson; Muhammad Tanweer Khan; Per‐Olof Bergh; Jee‐Hwan Oh, Cell Reports (2025) — licensed CC BY 4.0.
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Metadata source: OpenAlex · DOI 10.1016/j.celrep.2025.116434