Phylogenetic assessment of alignments reveals neglected tree signal in gaps
Christophe Dessimoz; Manuel Gil · 2010 · Genome biology
WASTE classifies this as Negative / Null Result Report · AI classification, approximate
The study found no significant effect — useful as a negative control or null benchmark for your own design.
Abstract
BACKGROUND: The alignment of biological sequences is of chief importance to most evolutionary and comparative genomics studies, yet the two main approaches used to assess alignment accuracy have flaws: reference alignments are derived from the biased sample of proteins with known structure, and simulated data lack realism. RESULTS: Here, we introduce tree-based tests of alignment accuracy, which not only use large and representative samples of real biological data, but also enable the evaluation of the effect of gap placement on phylogenetic inference. We show that (i) the current belief that
Abstract by Christophe Dessimoz; Manuel Gil, Genome biology (2010) — licensed CC BY 4.0.
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Metadata source: OpenAlex · DOI 10.1186/gb-2010-11-4-r37