HDAC inhibitors as anticancer drugs: chemical diversity, clinical trials, challenges and perspectives
A. AbdAllah · 2026 · RSC Advances
WASTE classifies this as Negative / Null Result Report · AI classification, approximate
The study found no significant effect — useful as a negative control or null benchmark for your own design.
Abstract
In an attempt to collect clinical data about HDAC inhibitors as very significant anticancer drugs we aimed to compare data and reveal the impact of the structural features, concluding the points of interest that are likely to help further development of better cancer therapy. We presented results of different clinical phases of HDAC inhibitors classified as hydroxamic acid derivatives, cyclic peptides, benzamides, and short chain aliphatic acids in a coherent and cohesive manner. It was found that HDAC inhibitors are preferentially combined with other antitumor drugs, mainly anti PD-1 and doxo
Abstract by A. AbdAllah, RSC Advances (2026) — licensed CC BY 4.0.
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Metadata source: OpenAlex · DOI 10.1039/d5ra09034b