Region-specific transcriptional signatures of brain aging in the absence of neuropathology at the single-cell level
Monica E. Mesecar; Megan F. Duffy; Dominic J. Acri; Jinhui Ding; Rebekah G. Langston; Syed I. Shah; Mike A. Nalls; Xylena Reed · 2026 · npj Aging
WASTE classifies this as Negative / Null Result Report · AI classification, approximate
The study found no significant effect — useful as a negative control or null benchmark for your own design.
Abstract
As age is a significant risk factor for multiple neurodegenerative diseases, investigating normal brain aging may help identify molecular events contributing to increased disease risk over time. Single-nucleus RNA sequencing (snRNA-seq) enables analysis of gene expression changes within specific cell-types, offering insights into the molecular mechanisms underlying aging. However, most brain aging snRNA-seq datasets use age-matched controls from studies focused on pathology and sample cortical regions. Therefore, there is a need to investigate non-pathological aging within brain regions vulner
Abstract by Monica E. Mesecar; Megan F. Duffy; Dominic J. Acri; Jinhui Ding; Rebekah G. Langston; Syed I. Shah; Mike A. Nalls; Xylena Reed, npj Aging (2026) — licensed CC BY 4.0.
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Metadata source: OpenAlex · DOI 10.1038/s41514-026-00391-9