The Ability of Different Imputation Methods to Preserve the Significant Genes and Pathways in Cancer
Rosa Aghdam; Taban Baghfalaki; Pegah Khosravi; Elnaz Saberi Ansari · 2017 · Genomics, Proteomics & Bioinformatics
WASTE classifies this as Negative / Null Result Report · AI classification, approximate
The study found no significant effect — useful as a negative control or null benchmark for your own design.
Abstract
Deciphering important genes and pathways from incomplete gene expression data could facilitate a better understanding of cancer. Different imputation methods can be applied to estimate the missing values. In our study, we evaluated various imputation methods for their performance in preserving significant genes and pathways. In the first step, 5% genes are considered in random for two types of ignorable and non-ignorable missingness mechanisms with various missing rates. Next, 10 well-known imputation methods were applied to the complete datasets. The significance analysis of microarrays (SAM)
Abstract by Rosa Aghdam; Taban Baghfalaki; Pegah Khosravi; Elnaz Saberi Ansari, Genomics, Proteomics & Bioinformatics (2017) — licensed CC BY 4.0.
About to run something similar?
Run an AI Precheck on your own design to catch failure modes like this one before you spend the time. Your first desk check is free.
Related failures
Genes of photoperiod sensitivity and early maturity E1-E4: dynamics of soybean growth in different daylength conditions
Negative / Null Result ReportPhosphorylation of RAV1/2 by KIN10 is essential for transcriptional activation of CAT6/7, which underlies oxidative stress response in cassava
Negative / Null Result ReportControl of Fusarium Wilt of Chili With Chitinolytic Bacteria
Negative / Null Result ReportEffects of deficit irrigation and kaolin application on vegetative growth and fruit traits of two early ripening apple cultivars
Negative / Null Result ReportIrregularities in Meiotic Prophase I as Prerequisites for Reproductive Isolation in Experimental Hybrids Carrying Robertsonian Translocations
Negative / Null Result ReportEffects of environmentally relevant ibuprofen and valproic acid exposure on zebrafish behavior
WASTE indexes this work — it does not host or republish it. Failure-type classification is automated and approximate.
Metadata source: DOAJ · DOI 10.1016/j.gpb.2017.08.003