Treatment Outcomes and Overall Survival of Patients With B‐Cell Prolymphocytic Leukemia
Daniel A. Ermann; Victoria A. Vardell; Lindsey Fitzgerald; Allison Bock; Harsh Shah; Boyu Hu; Deborah M. Stephens · 2026 · eJHaem
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Abstract
ABSTRACT Introduction B‐cell prolymphocytic leukemia (B‐PLL) is a rare, aggressive leukemic B‐cell malignancy historically associated with poor outcomes and recently reclassified in the WHO Fifth Edition but retained as a distinct entity in the ICC. Methods We analyzed 950 patients labeled as B‐PLL in the National Cancer Database (2004–2019), identified using ICD‐O‐3 morphology code 9833/3. Results Median age was 72 years, and 72% received systemic therapy at diagnosis. Median overall survival (OS) was poor (2.8 years) and did not improve over time. Patients initially managed with active surve
Abstract by Daniel A. Ermann; Victoria A. Vardell; Lindsey Fitzgerald; Allison Bock; Harsh Shah; Boyu Hu; Deborah M. Stephens, eJHaem (2026) — licensed CC BY 4.0.
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Metadata source: DOAJ · DOI 10.1002/jha2.70299