Dual signaling pathways of TGF-β superfamily cytokines in hepatocytes: balancing liver homeostasis and disease progression
Roohi Chaudhary; Ralf Weiskirchen; Marcelo Ehrlich; Yoav I. Henis · 2025 · Frontiers in Pharmacology
WASTE classifies this as Negative / Null Result Report · AI classification, approximate
The study found no significant effect — useful as a negative control or null benchmark for your own design.
Abstract
The transforming growth factor-β (TGF-β) superfamily (TGF-β-SF) comprises over 30 cytokines, including TGF-β, activins/inhibins, bone morphogenetic proteins (BMPs), and growth differentiation factors (GDFs). These cytokines play critical roles in liver function and disease progression. Here, we discuss Smad-dependent (canonical) and non-Smad pathways activated by these cytokines in a hepatocellular context. We highlight the connection between the deregulation of these pathways or the balance between them and key hepatocellular processes (e.g., proliferation, apoptosis, and epithelial-mesenchym
Abstract by Roohi Chaudhary; Ralf Weiskirchen; Marcelo Ehrlich; Yoav I. Henis, Frontiers in Pharmacology (2025) — licensed CC BY 4.0.
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Metadata source: OpenAlex · DOI 10.3389/fphar.2025.1580500