Pharmacological Evaluation of the SCID T Cell Transfer Model of Colitis: As a Model of Crohn's Disease
Thomas Lindebo Holm; Steen Seier Poulsen; Helle Markholst; Stine Louise Reedtz-Runge · 2012 · International Journal of Inflammation
WASTE classifies this as Negative / Null Result Report · AI classification, approximate
The study found no significant effect — useful as a negative control or null benchmark for your own design.
Abstract
Animal models are important tools in the development of new drug candidates against the inflammatory bowel diseases (IBDs) Crohn's disease and ulcerative colitis. In order to increase the translational value of these models, it is important to increase knowledge relating to standard drugs. Using the SCID adoptive transfer colitis model, we have evaluated the effect of currently used IBD drugs and IBD drug candidates, that is, anti-TNF-α, TNFR-Fc, anti-IL-12p40, anti-IL-6, CTLA4-Ig, anti-α4β7 integrin, enrofloxacin/metronidazole, and cyclosporine. We found that anti-TNF-α, antibiotics, anti-IL-
Abstract by Thomas Lindebo Holm; Steen Seier Poulsen; Helle Markholst; Stine Louise Reedtz-Runge, International Journal of Inflammation (2012) — licensed CC BY 4.0.
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Metadata source: OpenAlex · DOI 10.1155/2012/412178