Origins of chromosome instability unveiled by coupled imaging and genomics
Marco Raffaele Cosenza; Alice Gaiatto; Büşra Erarslan Uysal; Álvaro Andrades; Nina Luisa Sautter; Marina Simunovic; Michael Jendrusch; Sonia Zumalave · 2025 · Nature
WASTE classifies this as Negative / Null Result Report · AI classification, approximate
The study found no significant effect — useful as a negative control or null benchmark for your own design.
Abstract
, the underlying processes and rates of spontaneous CA formation in human cells are underexplored. Here we introduce machine-learning-assisted genomics and imaging convergence (MAGIC)-an autonomously operated platform that integrates live-cell imaging of micronucleated cells, machine learning on-the-fly and single-cell genomics to systematically investigate CA formation. Applying MAGIC to near-diploid, non-transformed cell lines, we track de novo CAs over successive cell cycles, highlighting the common role of dicentric chromosomes as initiating events. We determine the baseline CA mutation ra
Abstract by Marco Raffaele Cosenza; Alice Gaiatto; Büşra Erarslan Uysal; Álvaro Andrades; Nina Luisa Sautter; Marina Simunovic; Michael Jendrusch; Sonia Zumalave, Nature (2025) — licensed CC BY 4.0.
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Metadata source: OpenAlex · DOI 10.1038/s41586-025-09632-5