Revisiting the Role of Vitamin D in Fracture Prevention in the Era of Mega-Trials
Sung Hye Kong · 2026 · Endocrinology and Metabolism
WASTE classifies this as Negative / Null Result Report · AI classification, approximate
The study found no significant effect — useful as a negative control or null benchmark for your own design.
The finding, in one line
“However, recent large-scale randomized controlled trials have failed to replicate the broad benefits previously observed in epidemiological studies, particularly with respect to fracture and fall prevention in vitamin D-replete populations.”
Abstract
For decades, vitamin D has been a cornerstone of preventive medicine. However, recent large-scale randomized controlled trials have failed to replicate the broad benefits previously observed in epidemiological studies, particularly with respect to fracture and fall prevention in vitamin D-replete populations. Moreover, growing evidence suggesting an increased fall risk associated with high-dose bolus administration has necessitated a re-evaluation of safety assumptions. This review synthesizes these discordant findings to propose a framework grounded in precision medicine. We explore the ‘dive
Abstract by Sung Hye Kong, Endocrinology and Metabolism (2026) — licensed CC BY 4.0.
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Metadata source: DOAJ · DOI 10.3803/enm.2026.2938