Oral pathogens meet the gut microbiome: new mechanistic insights on systemic disease
Guowu Gan; Ruonan Chen; Peining Zheng; Kekao Long; Kenneth K. Ma; Jordy Evan Sulaiman; Xiaoyin Huang · 2026 · Frontiers in Cellular and Infection Microbiology
WASTE classifies this as Negative / Null Result Report · AI classification, approximate
The study found no significant effect — useful as a negative control or null benchmark for your own design.
Abstract
The oral-gut axis represents a critical bidirectional pathway linking oral microbiota to systemic health. Dysbiosis of the oral microbiome, driven by pathogens like Porphyromonas gingivalis, Fusobacterium nucleatum, Streptococcus species, and Helicobacter pylori, disrupts gut ecology via direct translocation, metabolite signaling (e.g., TMAO, SCFAs), and immune crosstalk (e.g., Th17). This leads to gut barrier dysfunction, systemic inflammation, and metabolic disturbances, contributing to diverse diseases beyond the oral cavity. Evidence supports causal links with conditions including rheumato
Abstract by Guowu Gan; Ruonan Chen; Peining Zheng; Kekao Long; Kenneth K. Ma; Jordy Evan Sulaiman; Xiaoyin Huang, Frontiers in Cellular and Infection Microbiology (2026) — licensed CC BY 4.0.
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Metadata source: OpenAlex · DOI 10.3389/fcimb.2025.1673512