Completion of tuberculosis preventive treatment with 300 mg vs. 100 mg isoniazid tablets: a pragmatic randomized clinical trial
João Paulo Cola; Thiago Nascimento do Prado; Bárbara Manuella Cardoso Sodré Alves; Carolina Maia Martins Sales; Bárbara Juliana Pinheiro Borges; Keila Cristina Mascarello; Anne Caroline Barbosa Cerqueira Vieira; Silvia das Dores Rissino · 2025 · BMC Infectious Diseases
WASTE classifies this as Negative / Null Result Report · AI classification, approximate
The study found no significant effect — useful as a negative control or null benchmark for your own design.
Abstract
Abstract Background Monotherapy with the drug isoniazid (INH) was for a long time the main therapeutic regimen used for tuberculosis preventive treatment (TPT). Research is progressing into the use of new therapeutic regimens that provide more complete TPT. The objective was to analyze the completion and safety of TPT with the drug INH in the form of 300 mg tablets. Methods Pragmatic, randomized, non-blinded, multicenter clinical trial conducted in Brazil from January 2019 to December 2022. Subjects over the age of 18 years with an indication for TPT was included and those whose index case of
Abstract by João Paulo Cola; Thiago Nascimento do Prado; Bárbara Manuella Cardoso Sodré Alves; Carolina Maia Martins Sales; Bárbara Juliana Pinheiro Borges; Keila Cristina Mascarello; Anne Caroline Barbosa Cerqueira Vieira; Silvia das Dores Rissino, BMC Infectious Diseases (2025) — licensed CC BY 4.0.
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Metadata source: DOAJ · DOI 10.1186/s12879-025-10678-z