ASSOCIATION BETWEEN FAS/FASL EXPRESSION AND RHEUMATOLOGICAL MANIFESTATIONS IN PATIENTS INFECTED WITH HTLV-1
Aline Cecy Rocha de Lima; Wandrey Roberto dos Santos Brito; Luciana Cristina Coelho Pantoja Santos; Gabriel dos Santos Pereira Neto; Dara da Costa Soares; Carolina de Alcântara Maneschy; Flávia Alcantara Coutinho Batista; Maria Eduarda Gonçalves Lemos · 2026 · Brazilian Journal of Infectious Diseases
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Abstract
Introduction: Fas and FasL are known modulators of cellular apoptosis in immunoregulation of the innate immune response, as well as in the elimination of defective cells, and may be associated with antiviral activity of HTLV-1 – infected cells. Understanding the immunological mechanisms involved in the progression of HTLV-1 – associated diseases may contribute to predicting the clinical prognosis of infected individuals. Objective: To evaluate mRNA expression of the apoptotic modulators FAS and FASL in patients infected with HTLV-1. Methods: A total of 54 HTLV-1 – infected individuals were eva
Abstract by Aline Cecy Rocha de Lima; Wandrey Roberto dos Santos Brito; Luciana Cristina Coelho Pantoja Santos; Gabriel dos Santos Pereira Neto; Dara da Costa Soares; Carolina de Alcântara Maneschy; Flávia Alcantara Coutinho Batista; Maria Eduarda Gonçalves Lemos, Brazilian Journal of Infectious Diseases (2026) — licensed CC BY 4.0.
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Metadata source: DOAJ · DOI 10.1016/j.bjid.2026.105460