CD57+ EMRA CD8+ T cells in cancer patients over 70: associations with prior chemotherapy and response to anti-PD-1/PD-L1 therapy
Cécile Gonnin; Michelle Leemans; Florence Canoui-Poitrine; Morgane Lebraud; Aurélien Corneau; Louise Roquebert; Philippe Caillet; Pierre Gay · 2024 · Immunity & Ageing
WASTE classifies this as Negative / Null Result Report · AI classification, approximate
The study found no significant effect — useful as a negative control or null benchmark for your own design.
Abstract
Abstract Background Immune ageing complicates cancer treatment in older individuals. While immunotherapy targeting the PD-1/PD-L1 pathway can reinvigorate T cells, these cells tend to become senescent with age. This study investigates different CD8+ T cell subsets usually associated with senescence, in cancer patients over 70 years old who are undergoing anti-PD-1/PD-L1 immunotherapy, and examines the relationship between these senescent cells and prior chemotherapy exposure. We analyzed data from the Elderly Cancer Patient (ELCAPA) cohort, which included 35 patients enrolled between March 201
Abstract by Cécile Gonnin; Michelle Leemans; Florence Canoui-Poitrine; Morgane Lebraud; Aurélien Corneau; Louise Roquebert; Philippe Caillet; Pierre Gay, Immunity & Ageing (2024) — licensed CC BY 4.0.
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Metadata source: DOAJ · DOI 10.1186/s12979-024-00487-4