mTOR-autophagy axis regulation by intermittent fasting promotes skeletal muscle growth and differentiation
Chen Xinyan; Wu Yajie; He Shangfan; Yang Yuefei; Li Junwei; Zhu Jiaqiao; Ju Huiming · 2025 · Nutrition & Metabolism
WASTE classifies this as Negative / Null Result Report · AI classification, approximate
The study found no significant effect — useful as a negative control or null benchmark for your own design.
Abstract
Abstract Intermittent fasting (IF) as a dietary intervention with potential health benefits has garnered significant attention in recent years. This study investigated the effects of varying fasting intensities on skeletal muscle growth using mouse models. Compared to the normal-diet (ND) control group, short-term fasting induced feeding amount-dependent alterations in skeletal muscle autophagy markers, characterized by elevated LC3B expression, reduced p62 levels, and decreased p-mTOR/mTOR ratio. Notably, short-term mild fasting (sMF) significantly upregulated myogenic (MYH, MyoD) and adipoge
Abstract by Chen Xinyan; Wu Yajie; He Shangfan; Yang Yuefei; Li Junwei; Zhu Jiaqiao; Ju Huiming, Nutrition & Metabolism (2025) — licensed CC BY 4.0.
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Metadata source: DOAJ · DOI 10.1186/s12986-025-01001-3