Phase I and II trial on infusional 5-fluorouracil and gefitinib in combination with preoperative radiotherapy in rectal cancer: 10-years median follow-up
Maria Antonietta Gambacorta; Antonino De Paoli; Marco Lupattelli; Giuditta Chiloiro; Angela Pia Solazzo; Brunella Barbaro; Sergio Alfieri; Fabio Maria Vecchio · 2018 · Clinical and Translational Radiation Oncology
WASTE classifies this as Negative / Null Result Report · AI classification, approximate
The study found no significant effect — useful as a negative control or null benchmark for your own design.
Abstract
Purpose: The aim of this study is to evaluate the long term survival of the addition of gefitinib to chemoradiotherapy (CRT) in locally advanced rectal cancer (LARC). Methods and materials: This previously published multicentre, open-label, phase I-II study, enrolled patients (pts) with LARC to receive CRT with concurrent 5-fluorouracil continuous intravenous infusion and a dose escalation of orally administered gefitinib, followed 6–8 weeks later by surgery. An intra-operative radiotherapy boost of 10 Gy was planned. Adjuvant chemotherapy was administrated in ypN1-2 pts. After a median f/u of
Abstract by Maria Antonietta Gambacorta; Antonino De Paoli; Marco Lupattelli; Giuditta Chiloiro; Angela Pia Solazzo; Brunella Barbaro; Sergio Alfieri; Fabio Maria Vecchio, Clinical and Translational Radiation Oncology (2018) — licensed CC BY 4.0.
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Metadata source: DOAJ · DOI 10.1016/j.ctro.2018.02.003