Genome-wide analysis of 53,400 people with irritable bowel syndrome highlights shared genetic pathways with mood and anxiety disorders
Chris Eijsbouts; Tenghao Zheng; Nicholas A. Kennedy; Ferdinando Bonfiglio; Carl A. Anderson; Loukas Moutsianas; Jo Holliday; Jingchunzi Shi · 2021 · Nature Genetics
WASTE classifies this as Negative / Null Result Report · AI classification, approximate
The study found no significant effect — useful as a negative control or null benchmark for your own design.
Abstract
Abstract Irritable bowel syndrome (IBS) results from disordered brain–gut interactions. Identifying susceptibility genes could highlight the underlying pathophysiological mechanisms. We designed a digestive health questionnaire for UK Biobank and combined identified cases with IBS with independent cohorts. We conducted a genome-wide association study with 53,400 cases and 433,201 controls and replicated significant associations in a 23andMe panel (205,252 cases and 1,384,055 controls). Our study identified and confirmed six genetic susceptibility loci for IBS. Implicated genes included NCAM1 ,
Abstract by Chris Eijsbouts; Tenghao Zheng; Nicholas A. Kennedy; Ferdinando Bonfiglio; Carl A. Anderson; Loukas Moutsianas; Jo Holliday; Jingchunzi Shi, Nature Genetics (2021) — licensed CC BY 4.0.
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Metadata source: OpenAlex · DOI 10.1038/s41588-021-00950-8