MicroRNA-124-loaded nanoparticles increase survival and neuronal differentiation of neural stem cells in vitro but do not contribute to stroke outcome in vivo.
Cláudia Saraiva; Daniela Talhada; Akhilesh Rai; Raquel Ferreira; Lino Ferreira; Liliana Bernardino; Karsten Ruscher · 2018 · PLoS ONE
WASTE classifies this as Negative / Null Result Report · AI classification, approximate
The study found no significant effect — useful as a negative control or null benchmark for your own design.
Abstract
There is a high quest for novel therapeutic strategies to enhance recovery after stroke. MicroRNA-124 (miR-124) has been described as neuroprotective and anti-inflammatory molecule. Moreover, miR-124 is a well described enhancer of adult neurogenesis that could offer potentially beneficial effects. Herein, we used miR-124-loaded nanoparticles (miR-124 NPs) to evaluate their therapeutic potential in an in vitro and in vivo model of stroke. For that, neuroprotective and neurogenic responses were assessed in an in vitro model of stroke. Here, we found that miR-124 NPs decreased cell death and imp
Abstract by Cláudia Saraiva; Daniela Talhada; Akhilesh Rai; Raquel Ferreira; Lino Ferreira; Liliana Bernardino; Karsten Ruscher, PLoS ONE (2018) — licensed CC BY 4.0.
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Metadata source: DOAJ · DOI 10.1371/journal.pone.0193609