Can exercise affect immune function to increase susceptibility to infection?
Richard J. Simpson; Richard J. Simpson; Maree Gleeson; Maree Gleeson; Karsten Kruger; David B. Pyne; David B. Pyne; Neil P. Walsh · 2026 · PubMed
WASTE classifies this as Negative / Null Result Report · AI classification, approximate
The study found no significant effect — useful as a negative control or null benchmark for your own design.
Abstract
Multiple studies in humans and animals have demonstrated the profound impact that exercise can have on the immune system. There is a general consensus that regular bouts of short-lasting (i.e. up to 45 minutes) moderate intensity exercise is beneficial for host immune defense, particularly in older adults and people with chronic diseases. In contrast, infection burden is reported to be high among high performance athletes and second only to injury for the number of training days lost during preparation for major sporting events. This has shaped the common view that arduous exercise (i.e. those
Abstract by Richard J. Simpson; Richard J. Simpson; Maree Gleeson; Maree Gleeson; Karsten Kruger; David B. Pyne; David B. Pyne; Neil P. Walsh, PubMed (2026) — licensed CC BY 4.0.
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Metadata source: OpenAlex · DOI 10.22029/eir.2020.1730