Vitamin D in Cardiovascular Medicine: From Molecular Mechanisms to Clinical Translation
Fahimeh Varzideh; Pasquale Mone; Urna Kansakar; Gaetano Santulli · 2026 · Nutrients
WASTE classifies this as Replication Failure · AI classification, approximate
A previously reported effect did not replicate here — verify it holds before you build on it.
Abstract
Vitamin D, a fat-soluble secosteroid traditionally recognized for skeletal health, exerts pleiotropic effects on cardiovascular physiology and disease. Circulating 25-hydroxyvitamin D [25(OH)D], the principal biomarker of vitamin D status, is frequently suboptimal worldwide, particularly in older adults, individuals with darker skin pigmentation, and populations at higher latitudes. Observational studies consistently associate low 25(OH)D concentrations with increased risk of hypertension, atherosclerosis, myocardial infarction, heart failure, arrhythmias, stroke, and cardiovascular mortality.
Abstract by Fahimeh Varzideh; Pasquale Mone; Urna Kansakar; Gaetano Santulli, Nutrients (2026) — licensed CC BY 4.0.
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WASTE indexes this work — it does not host or republish it. Failure-type classification is automated and approximate.
Metadata source: OpenAlex · DOI 10.3390/nu18030499