A Phase 2 Trial of RANKL Antibody, Denosumab, in Two Cohorts of Patients with Recurrent/Refractory Osteosarcoma, a Report from the Children's Oncology Group.
Janeway KA; Chou AJ; Buxton A; Reid J; Isakoff MS; Kopp L; Hingorani P; Lee JL · 2026 · Clinical cancer research : an official journal of the American Association for Cancer Research
WASTE classifies this as Negative / Null Result Report · AI classification, approximate
The study found no significant effect — useful as a negative control or null benchmark for your own design.
Abstract (excerpt)
Purpose Mouse models demonstrate a role for RANK and its ligand, RANKL, in osteosarcoma. The primary objective of this single-arm, open-label phase 2 trial was to determine whether denosumab, a RANKL mAb, improved disease control in…
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Metadata source: Europe PMC · DOI 10.1158/1078-0432.ccr-24-2885