Loss of Protease Dimerization Inhibition Activity of Darunavir Is Associated with the Acquisition of Resistance to Darunavir by HIV-1
Yasuhiro Koh; Manabu Aoki; Matthew Danish; Hiromi Aoki-Ogata; Masayuki Amano; Debananda Das; Robert W. Shafer; Arun K. Ghosh · 2011 · Journal of Virology
WASTE classifies this as Negative / Null Result Report · AI classification, approximate
The study found no significant effect — useful as a negative control or null benchmark for your own design.
Abstract (excerpt)
Dimerization of HIV protease is essential for the acquisition of protease's proteolytic activity. We previously identified a group of HIV protease dimerization inhibitors, including darunavir (DRV). In the present work, we examine whether…
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Metadata source: OpenAlex · DOI 10.1128/jvi.05121-11