Comorbidity of Glucose-6-Phosphate Dehydrogenase Deficiency and Sickle Cell Disease Exert Significant Effect on RBC Indices
Samuel Antwi‐Baffour; Jonathan Kofi Adjei; Peter Owadee Forson; Stephen Akakpo; Ransford Kyeremeh; Mahmood Abdulai Seidu · 2019 · Anemia
WASTE classifies this as Negative / Null Result Report · AI classification, approximate
The study found no significant effect — useful as a negative control or null benchmark for your own design.
Abstract
BACKGROUND: Glucose-6-phosphate dehydrogenase (G6PD) converts glucose-6-phosphate into 6-phosphogluconate in the pentose phosphate pathway and protects red blood cells (RBCs) from oxidative damage. Their deficiency therefore makes RBCs prone to haemolysis. Sickle cell disease (SCD) on the other hand is a hereditary blood disorder in which there is a single nucleotide substitution in the codon for amino acid 6 substituting glutamic acid with valine. SCD patients are prone to haemolysis due to the shape of their red blood cells and if they are deficient in G6PD, the haemolysis may escalate. Repo
Abstract by Samuel Antwi‐Baffour; Jonathan Kofi Adjei; Peter Owadee Forson; Stephen Akakpo; Ransford Kyeremeh; Mahmood Abdulai Seidu, Anemia (2019) — licensed CC BY 4.0.
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Metadata source: OpenAlex · DOI 10.1155/2019/3179173